Rhinoscleroma.
نویسندگان
چکیده
Rhinoscleroma is a progressive, granulomatous infectious disease, usually limited to the upper respiratory tract and produced by Klebsiella rhinoscleromatis 1,2 . Sporadic cases and endemic foci of the disease have been found in 68 countries 3,4 . Clinically, the disease has been described in progressive stages; however overlapping of the stages occur frequently in the individual patient 3,5-7 . Other Investigators 8,9 have considered the Mikulicz cell as a macrophage. The foamy mononuclear cell in rhinoscieroma has all the basic morphologic structures characteristic of m acrophages 10 . The typical histopathology consists of plasma cells, lymphocytes, Russell bodies, Mikulicz cells and gram negative bacilli 11 . The Mikulicz cells are foamy vacuolated histiocytes under going hydropic degeneration in different stages 12 . These cells are well stained with hematoxylin eosin. Klebsiella rhinoscieromatis are found inside the Mikulicz cells and inter cellular spaces as gram negative diplobacilli. Microscopically the tumor shows polypoidal fragments. The subepithelial tissue reveals aggregates of foamy macrophages admixed with plasma cell. Many plasma cells contain fine cytoplasmic vacuoles, and the cytoplasm of others appear more eosinophilic than the amphophilia more commonly observed.
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Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae
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ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2000